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Myeloid Delivery
// Peripheral T-cell Lymphoma

MT-101 IMAGINE Phase 1/2 Study

MT-101 is being developed for the treatment of relapsed and refractory CD5-expressing T-cell lymphomas. Refractory PTCL is a lethal disease with limited treatment options that, until now, has not benefited from innovations in cell therapy. In vitro and in vivo studies show MT-101 demonstrated meaningful anti-tumor activity.

// Advanced or Metastatic Epithelial Tumors

MT-302 SYMPHONY Phase 1 Study

MT-302 represents the first candidate in an entirely new, therapeutic modality. It is a first-in-class, TROP2-FcA-LNP, with a strong preclinical profile that supports its advance into this first-in-human trial. TROP2 is overexpressed in most human solid epithelial cancers, with lower expression in corresponding normal tissue. Increased TROP2 expression has been linked to tumor growth.

// We are recruiting for clinical trials

Join our Studies

Myeloid has dosed its first patient in the IMAGINE study — a Phase 1/2, multicenter, open-label, dose-escalation, and dose cohort expansion clinical trial evaluating MT-101 in patients with refractory or relapsed PTCL. The dose-escalation portion of this Phase 1 study is currently open and enrolling patients with and without conditioning therapy.

Myeloid has also started dosing patients in the Symphony Study for MT-302 – a Phase 1 study (NCT05969041), which is an open-label dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of MT-302 in adults with advanced or metastatic epithelial tumors that overexpress TROP2. This study will also define the recommended Phase 2 dose (RP2D) of MT-302. The study is currently enrolling patients at multiple clinical sites in Australia.

Once Myeloid establishes the recommended Phase 2 dose, a Phase 2 trial will be initiated to support registration in this patient population.

Myeloid Patients Clinical Trials

    // Expanded Access

    Access to MT-101 Outside of a Clinical Trial Is Not Currently Available

    We recognize the unmet treatment need in patients with T-cell lymphoma who do not qualify for a clinical trial. Myeloid will put into place an expanded access policy once more therapeutic experience is available.